The newest resident physicians in the ER at Central University include talented Dongyan, last-place student Gengming, Hard-working Tangxi. Under the leadership of medical legends Chengjun and Yuhua, they race the clock to save lives; At the same time, they treat patients from all walks of life and grapple with the choices they must make in their profession.
Doctors not only fight the tug-of-war between life and death but also face the constraints of the medical system and the test of human nature, fame, and fortune.
Chengjun decides to publish his paper on a new medication despite tremendous pressure; this has induced a nasty power struggle at Central University Hospital. While Chengjun and Yuhua are facing a crisis of dismissal, Gengming leads the R1s to against the huge medical system, not only with their superior medical skills but with the conviction to save lives that first led them to become doctors.